Alterations in the gut microbiome shown as a problem in people with high cholesterol/high blood pressure

[BackInTheGame78]

Researchers unlock another finding...certain bacteria in the gut are responsible for breaking down cholesterol and in people who have high cholesterol, these bacteria are either far lower in number than people with normal cholesterol or missing altogether.

Not surprising honestly. Humans have evolved to literally require gut bacteria to help the body do it's job and function properly. Call it "passing off the grunt work" or whatever you want to call it, but that grunt work is vitally important to our overall health and when it's not being done properly, big issues occur...

As we kept finding out, virtually every issue you have health wise can be traced back to poor gut microbiome or lack of proper diversity of the gut microbiome that causes negative consequences over time...

Another study is underway to see if animal models hold true and that leaky gut is the cause of high blood pressure in many people...again, caused by poor gut microbiome health...

Harvard and MIT Scientists Discover Cholesterol-Busting Microbes in the Gut

New research to determine link between high blood pressure and gut health | Heart Foundation

New research funded by the Heart Foundation will investigate whether poor gut health is a cause of high-blood pressure.

www.heartfoundation.org.au

 

[EyeBRollin]

Gut micro biome is crucial. However, it is not the primary pathway in cholesterol issues. 70-80% of cholesterol is endogenous. People with genetic high cholesterol are hyper producers, have faulty cholesterol clearance (aka LDL receptors), or are hyper absorbers. Gut influences of high cholesterol applies to the hyper absorbers. The healthiest gut micro biome will not fix the problem of hyper production or faulty cholesterol clearance. Thankfully, we have modern medicine.

 

[BackInTheGame78]

Gut micro biome is crucial. However, it is not the primary pathway in cholesterol issues. 70-80% of cholesterol is endogenous. People with genetic high cholesterol are hyper producers, have faulty cholesterol clearance (aka LDL receptors), or are hyper absorbers. Gut influences of high cholesterol applies to the hyper absorbers. The healthiest gut micro biome will not fix the problem of hyper production or faulty cholesterol clearance. Thankfully, we have modern medicine.

You are forgetting about one thing. Their role in gene expression. And that WOULD potentially fix that issue if the wrong genes are being expressed. They would need to do more studies and research obviously to see if that is linked.

 

[EyeBRollin]

You are forgetting about one thing. Their role in gene expression. And that WOULD potentially fix that issue if the wrong genes are being expressed. They would need to do more studies and research obviously to see if that is linked.

So the research would study the gut micro biome’s affect to the liver’s cholesterol production?

 

[BackInTheGame78]

So the research would study the gut micro biome’s affect to the liver’s cholesterol production?

Gene expression is kinda complicated. Basically there are various things that can either turn on or turn off genes to be expressed like a switch. Turned on means it functions as it should, turned off means it doesn't function as it should.

Vitamin D(which isn't a vitamin at all, rather a pro hormone), Zinc and gut bacteria are 3 things that can effect different parts of the genome.

Where and what exactly these control is still being found, Vitamin D controls gene expression for much of the immune system and many genes expressing for cancers and Zinc controls it for much of the "maleness" genes in men(ie, inhibiting aramotization of T).

Where and how gut bacteria factor into this is still not known to a large extent, only that it seemingly effects the entire system as a whole.