I disagree.
You can do something to help your brother out, without pointing out the fact that he 'plays video games too much' or 'isn't interested in girls yet'.
If you really want to help your brother, there are ways you can do it, subtly.
Take him out some night to shoot a few games of pool. Make it a casual thing, you guys go out with a few buddies together every week or so and shoot pool. This will get him out of the house and doing something with people, and hopefully he'll enjoy playing pool and he'll have a new hobby. This benefits him in that he'll improve his pool game the more he plays, and will grow more confident because of this, and he'll be out interacting with other people.
After a while, see if your brother will start working out with you. After seeing that he has fun doing things with you from shooting pool, he should be quick to accept. Working out will increase his confidence drastically, and get him in better shape. Girls may start taking notice into HIM, seeing how he is working out and enjoys his hobbies.
Now you let him have his painful ordeals. His heartbreaks. His
experiences.
And then you know what will happen? Once he reaches his 'breaking point', he'll seek a way to change himself, and he'll go to somebody for advice. His brother, who thankfully for him, has a whole wealth on DJ knowledge.
There's your solution. You get him started in life, doing something, and attract the girls to him...Then let him experience everything life has to offer him from there.