In case there was any doubt, yet another study shows that a ketogenic diet - meat, fish, eggs etc - where you make your body used to burning fat beats the typical American habit of filling yourself with sugar from carbs. But those who want to keep their bread-and-pasta habit are welcome to ignore this study by zeroing in on the fact that it was done with mice, thereby revealing their ignorance about actual research.
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30490-4
Highlights
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30490-4
Highlights
- •A low-carbohydrate, ketogenic diet extends longevity in adult male mice
- •Motor function, memory, and muscle mass are preserved in aged ketogenic mice
- •Protein acetylation is increased in the liver and skeletal muscle of ketogenic mice
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.
