Bold is always the way to go. No one said you weren't going to piss off some dudes by being the alpha male. Women like men who aren't afraid of confrontation.
When I open a mixed set I always keep the focus on the women for the first few minutes. It gets them interested and I get to show them a little bit of who I am (the guy who will have you laughing so hard your panties are wet by the time i'm done talking to you). Once I feel like I've made my presence known, I'll start talking with the men of the group and try to solidify myself as someone who they could definitely talk to if they ever needed to. I like to come on as a best friend who could give them advice on almost anything. Most guys eat this **** up.. they see you as someone with a lot of experience/knowledge who is willing to help them.
Believe it or not, I DO like to introduce myself to the guys in a mixed set. It immediately takes away any intimidation factor I may have and thus let's me run the conversation without any stupid ****ing looks or anything like that. Once you've made it in the with the guys, you can talk to these people how ever you want to. You can talk about how big their friend's ass is just because they know you are a friend and can joke about their girls. Friends joke around about women. Then you move on to making jokes about how one of their friends can't keep her mouth shut and obviously needs something to pacify her, and they still laugh. You are their knowledgable friend now, why wouldn't they laugh? After all, they are learning from you that women like sexual notation when you're talking to them. Most men feel on top of the world when another guy who seems of higher status introduces themselves to them. It gives them a sort of (false) self sense of comfort that he would NOT steal the women they are with.
My motto is you snooze, you lose. I find that most men who go out with girls to clubs and bars are usually "just friends" aka slouches aka AFCs and have been living under a rock for the past 10 years as far as women are concerned. I don't feel bad at all when I steal their women because after all, it's a dog eat dog world out there. If you are too boring in yourself to show the women you are with a good time, there is a guy that sure as hell will.