marmel75
Master Don Juan
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A substance that has been talked about for several years now, Buckminsterfullerene(aka "Bucky Balls" due to its structure that looks like a ball) has showed it has significant life-extending properties a few years ago, and occurs naturally in a the Shungite mineral of Russian healing springs....its also called C60...
Apparently it was able to double rat's life expectancy and had no toxicity...
http://owndoc.com/anti-aging/buy-buckminsterfullerene-c60-natural-anti-aging/
http://c60antiaging.com/c60-antiaging/how-does-c60-extend-life/
http://joshmitteldorf.scienceblog.com/2013/01/29/63/
http://www.kurzweilai.net/fullerene-c60-administration-doubles-rat-lifespan-with-no-toxicity
Here is a study regarding its MOA and findings: In plain English, its able to get to the "dirtiest place in the cell", where the mitochondria operates to produce energy and scavenge the waste byproducts of this exceptionally well, "scrubbing" the cell clean from the inside out.
With the waste byproduct quickly removed, it basically "Supercharges" the mitochondria(aka the powerplant of the cell).
Mechanism of Action:
Results:
According to our model fullerene C60 accumulating in mitochondria provides high radical scavenging activity in this subcellular compartment, called by Skulachev the “dirtiest place in the cell” [28]. Another effective antioxidant mechanism is based on mild uncoupling of respiration and phosphorylation. Respiratory chain obtains electrons from NADH and succinate. They are used for harmless four-electron reduction of oxygen. But the transfer of one or two electrons could produce the radicals that are dangerous to cells (such as superoxide or peroxide anions).
The specific feature attributable to the generation of ROS by mitochondria is related to the fact that the higher is the membrane potential (the larger is the difference in the concentration of protons inside and outside the mitochondria), the higher is the level of the superoxide anion production. As it was shown [29], there is steep dependence of mitochondrial superoxide-anion-radical generation on transmembrane potential (Δ). Even a small (10–15%) decline of Δ resulted in tenfold lowering of ROS production rate.
Therefore, the so-called mild uncouplers of oxidative phosphorylation are the substances which can move some of the protons inside the mitochondria and can possess an excellent oxygen-protective effect, although they are not antioxidants in terms of chemistry [19].
DFT simulations allowed us to propose the following mechanism. C60 fullerene molecules enter the space between inner and outer membranes of mitochondria, where the excess of protons has been formed by diffusion. In this compartment fullerenes are loaded with protons and acquire positive charge distributed over their surface. Such “charge-loaded’’ particles can be transferred through the inner membrane of the mitochondria due to the potential difference generated by the inner membrane, using electrochemical mechanism described in detail by Skulachev et al. [18, 24]. In this case the transmembrane potential is reduced, which in turn significantly reduces the intensity of superoxide anion-radical production.
5. Conclusion
The proposed ability of C60 fullerenes to acquire positive charge allows ascribing them to the mitochondrial-targeted compounds. The key role of mitochondria in the cellular regulation makes such “charge-loaded” fullerenes be of great interest along the route for novel classes of drugs development."
http://www.hindawi.com/journals/bmri/2013/821498/
For this reason by itself, I would be very interested in taking it...But this is only the START of where the fun begins---keep reading for the PED benefits of this compound:
WHOA....look at these reputed results in people taking this---very interesting for bodybuilding/weight training/aerobic training:
-Can lift much heavier weights, sometimes to the point of causing tendon injury. Commonly reported.
-Can do more reps of the same weight. This was the most commonly reported benefit. People were ADAMANT that there was a great difference, comparable to taking Creatine and that NOT EVEN ANABOLIC STEROIDS enabled such an immediate increase of both repetitions and max weight
-Calmer, reduction in stress
-Can run longer with seemingly more effective utilization of Oxygen. Less fatigue. “Cardiac improvements”. Better stamina and endurance.
-Can run faster whilst feeling more comfortable with a pulse that would normally be too high for steady-state.
-Higher libido. This is also seen in rat trials, already with 4 micrograms/kg, a dose five times lower than what we recommend as a daily dose.
And a post in favor from Suppversity, which I highly respect---claiming it might be the most liver-protective substance ever found:
http://suppversity.blogspot.com/2012/04/soccer-molecule-of-youth-fullerene-c60.html
Here is one person who trains regularly and heavily's report after 90 days on C60:
"Now that I have had about 90 days of using C60, I think I feel comfortable summarizing the main points of my experience..
-I have definitely established a new baseline of performance & recovery that seems to have leveled off after the first 30 days or so of use. I continue to take 3mg twice weekly and plan on maintaining this indefinitely.
-I found that during the first few weeks of use I experienced a profound change in my ability to recover from exercise as well as a significant increase in delayed onset of muscle fatigue.
The ability to quickly recover to a normal baseline state after intense exercise seems to be the most significant effect for me. It continues to this day.
-Regarding delayed onset of muscle fatigue - it is most apparent when doing short / explosive type movements that are high repetition, C60 really seems to shine in this area, giving not only a greater burst of power output but for much longer periods of time.
-Interestingly, in pure aerobic conditions (ie distance running) I noted no real effects other than the side benefit of greatly enhanced recovery after the runs.
-Initially I seemed to experience some improvement in skin tone and wrinkles, however, these effects were either placebo or did not last.
-I have not noted any faster wound healing, but (fortunately) I have not had anything major other than a few cuts and scrapes.
-My immune system seems much more responsive and able to fight off infection. I have had sinus/allergy issues my entire life and no longer even have a hint of those issues. However, I can attribute that a lot of other factors as well. (MOD-GRF / IPA use)
-I have also noted that C60 seems to exert some anti-inflammatory effects. My overall joint health is much better than pre-C60.
My eyesight has improved slightly, after a long history of slowly getting worse.
-I have noticed that their are some short term effects immediately after dosing such as increased clarity / mental energy. I don't know if this is just due to the olive oil, however. These effects seem to fade in about 4 hrs.
In summary, my experience with C60 has been life changing - as the better portion of my life outside work, family, is fitness related and this is where C60 has really had a real impact for me. "
His log can be read here:
http://www.longecity.org/forum/topic/64769-c60-log-buckyballs-exercise-and-me/
At one point in the log he said that he had done a certain drill with log carrying many, many times, hundreds in fact and as hard as he pushed at 100% effort, it still took him 22 minutes to complete. Within a few weeks on C60 he was completing it in under 15 minutes.
"The past couple of weeks have gone well, I definitely feel that I am retaining the effects of C60, at least thus far. I am still taking 6mg twice weekly and have no plans to change that schedule. I can now complete the log-exercise workout in under 15 minutes, when my previous best, prior to C60 was about 22 min. Its likely coming from a much greater delay in muscle fatigue and the reduced need to rest between sets (2min vs. 4 min previously). As I stated earlier I have done over 100 of those exact same log-exercise workouts and 22 minutes was the best I could achieve at 100% effort. I have suddenly cut close to 8 minutes off that time so that (in my mind at least) is quantifiable evidence that these effects are real."
Apparently it was able to double rat's life expectancy and had no toxicity...
http://owndoc.com/anti-aging/buy-buckminsterfullerene-c60-natural-anti-aging/
http://c60antiaging.com/c60-antiaging/how-does-c60-extend-life/
http://joshmitteldorf.scienceblog.com/2013/01/29/63/
http://www.kurzweilai.net/fullerene-c60-administration-doubles-rat-lifespan-with-no-toxicity
Here is a study regarding its MOA and findings: In plain English, its able to get to the "dirtiest place in the cell", where the mitochondria operates to produce energy and scavenge the waste byproducts of this exceptionally well, "scrubbing" the cell clean from the inside out.
With the waste byproduct quickly removed, it basically "Supercharges" the mitochondria(aka the powerplant of the cell).
Mechanism of Action:
Results:
According to our model fullerene C60 accumulating in mitochondria provides high radical scavenging activity in this subcellular compartment, called by Skulachev the “dirtiest place in the cell” [28]. Another effective antioxidant mechanism is based on mild uncoupling of respiration and phosphorylation. Respiratory chain obtains electrons from NADH and succinate. They are used for harmless four-electron reduction of oxygen. But the transfer of one or two electrons could produce the radicals that are dangerous to cells (such as superoxide or peroxide anions).
The specific feature attributable to the generation of ROS by mitochondria is related to the fact that the higher is the membrane potential (the larger is the difference in the concentration of protons inside and outside the mitochondria), the higher is the level of the superoxide anion production. As it was shown [29], there is steep dependence of mitochondrial superoxide-anion-radical generation on transmembrane potential (Δ). Even a small (10–15%) decline of Δ resulted in tenfold lowering of ROS production rate.
Therefore, the so-called mild uncouplers of oxidative phosphorylation are the substances which can move some of the protons inside the mitochondria and can possess an excellent oxygen-protective effect, although they are not antioxidants in terms of chemistry [19].
DFT simulations allowed us to propose the following mechanism. C60 fullerene molecules enter the space between inner and outer membranes of mitochondria, where the excess of protons has been formed by diffusion. In this compartment fullerenes are loaded with protons and acquire positive charge distributed over their surface. Such “charge-loaded’’ particles can be transferred through the inner membrane of the mitochondria due to the potential difference generated by the inner membrane, using electrochemical mechanism described in detail by Skulachev et al. [18, 24]. In this case the transmembrane potential is reduced, which in turn significantly reduces the intensity of superoxide anion-radical production.
5. Conclusion
The proposed ability of C60 fullerenes to acquire positive charge allows ascribing them to the mitochondrial-targeted compounds. The key role of mitochondria in the cellular regulation makes such “charge-loaded” fullerenes be of great interest along the route for novel classes of drugs development."
http://www.hindawi.com/journals/bmri/2013/821498/
For this reason by itself, I would be very interested in taking it...But this is only the START of where the fun begins---keep reading for the PED benefits of this compound:
WHOA....look at these reputed results in people taking this---very interesting for bodybuilding/weight training/aerobic training:
-Can lift much heavier weights, sometimes to the point of causing tendon injury. Commonly reported.
-Can do more reps of the same weight. This was the most commonly reported benefit. People were ADAMANT that there was a great difference, comparable to taking Creatine and that NOT EVEN ANABOLIC STEROIDS enabled such an immediate increase of both repetitions and max weight
-Calmer, reduction in stress
-Can run longer with seemingly more effective utilization of Oxygen. Less fatigue. “Cardiac improvements”. Better stamina and endurance.
-Can run faster whilst feeling more comfortable with a pulse that would normally be too high for steady-state.
-Higher libido. This is also seen in rat trials, already with 4 micrograms/kg, a dose five times lower than what we recommend as a daily dose.
And a post in favor from Suppversity, which I highly respect---claiming it might be the most liver-protective substance ever found:
http://suppversity.blogspot.com/2012/04/soccer-molecule-of-youth-fullerene-c60.html
Here is one person who trains regularly and heavily's report after 90 days on C60:
"Now that I have had about 90 days of using C60, I think I feel comfortable summarizing the main points of my experience..
-I have definitely established a new baseline of performance & recovery that seems to have leveled off after the first 30 days or so of use. I continue to take 3mg twice weekly and plan on maintaining this indefinitely.
-I found that during the first few weeks of use I experienced a profound change in my ability to recover from exercise as well as a significant increase in delayed onset of muscle fatigue.
The ability to quickly recover to a normal baseline state after intense exercise seems to be the most significant effect for me. It continues to this day.
-Regarding delayed onset of muscle fatigue - it is most apparent when doing short / explosive type movements that are high repetition, C60 really seems to shine in this area, giving not only a greater burst of power output but for much longer periods of time.
-Interestingly, in pure aerobic conditions (ie distance running) I noted no real effects other than the side benefit of greatly enhanced recovery after the runs.
-Initially I seemed to experience some improvement in skin tone and wrinkles, however, these effects were either placebo or did not last.
-I have not noted any faster wound healing, but (fortunately) I have not had anything major other than a few cuts and scrapes.
-My immune system seems much more responsive and able to fight off infection. I have had sinus/allergy issues my entire life and no longer even have a hint of those issues. However, I can attribute that a lot of other factors as well. (MOD-GRF / IPA use)
-I have also noted that C60 seems to exert some anti-inflammatory effects. My overall joint health is much better than pre-C60.
My eyesight has improved slightly, after a long history of slowly getting worse.
-I have noticed that their are some short term effects immediately after dosing such as increased clarity / mental energy. I don't know if this is just due to the olive oil, however. These effects seem to fade in about 4 hrs.
In summary, my experience with C60 has been life changing - as the better portion of my life outside work, family, is fitness related and this is where C60 has really had a real impact for me. "
His log can be read here:
http://www.longecity.org/forum/topic/64769-c60-log-buckyballs-exercise-and-me/
At one point in the log he said that he had done a certain drill with log carrying many, many times, hundreds in fact and as hard as he pushed at 100% effort, it still took him 22 minutes to complete. Within a few weeks on C60 he was completing it in under 15 minutes.
"The past couple of weeks have gone well, I definitely feel that I am retaining the effects of C60, at least thus far. I am still taking 6mg twice weekly and have no plans to change that schedule. I can now complete the log-exercise workout in under 15 minutes, when my previous best, prior to C60 was about 22 min. Its likely coming from a much greater delay in muscle fatigue and the reduced need to rest between sets (2min vs. 4 min previously). As I stated earlier I have done over 100 of those exact same log-exercise workouts and 22 minutes was the best I could achieve at 100% effort. I have suddenly cut close to 8 minutes off that time so that (in my mind at least) is quantifiable evidence that these effects are real."
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