If it's during the handshake, it might just be a peculiar way they have of shaking, or your hands fit oddly because of size.
if this is during hand holding, when she's stroking your hand, YOU'RE MONEY. The ONLY time this has happened to me is when the girl is just WAITING to get busy.
If you want to initiate things, point it out, and give her the knowing smirk, draw your hand in (still holding hers) across your body so her and and yours are on your pec. Unless she's freakishly abnormal, at this point, she'll be quite close to you, and by sliding your hands down your chest, she'll get closer, and now you kiss her. ALTERNATELY, after you get your hand and hers to your chest, you can raise it over her head as you pull her in, and settle it on the back of your neck, and suddenly you are in PRIME kissing position.
Madison Kain